Gebze Technical University

Photobiology Laboratory

Laboratory Name	Photobiology Laboratory
Laboratory Responsible	Assist. Prof. Nil Saydan
Department	Molecular Biology and Genetics
Telephone	+90 (262) 605 2520 veya 2546
Address	Gebze Institute of Technology Department of Molecular Biology and Genetics C-2/218/237 41400 Cayirova, Kocaeli, TURKEY
General Information	Studies carried out in our laboratory concern the research on Photodynamic therapy (PDT) that is used in recent years with increasing interest for the treatment of some diseases. We aimed in our studies to determine appropriate photosensitizer (phthalocyanines) that are suitable for photodynamic therapy. Also we aimed to develop effective delivery systems for photosensitizer such as nanoparticules. The aim of another our recent research concern the conjugation of enzyme/prodrug systems with nanoparticles and investigation of suitability of combination of these systems with photodynamic therapy. Our goals are; 1. Investigating photodynamic therapy effects on the cell death mechanisms and in the cell cycle: for this purpose we use novel photosynthesizers that are synthesized in Chemistry Department of our Faculty. 2. Developing carrier systems such as nanoparticles that provide easy uptake by cancer cells. 3. Developing enzyme/prodrug systems administered on cancer cells. 4. Supporting and teaching Master and PhD Students.
Laboratory Staff	Esra Kaya (MSc student) Elif Sırma (MSc student) Meltem Göksel (PhD student)
Applications	1.Subculturing and storage of the cells for experiments 2.Photobiology studies in cell systems a. toxicity experiments in photosynthesizers in various concentrations b. toxicity experiments of light in various energy levels c. toxicity experiments of photosynthesizers and light combinations d. the effect of photosynthesizers and light combination on the cell death and cell cycle mechanisms experiments e. development of photosynthesizer carrier systems such as nanoparticles f. in vitro experiments on development of enzyme/prodrug systems for cancer therapy.
Equipment	1. CO2 incubator, 2. Sterile cabinet 3. Halogen light source equipment