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LİSANSÜSTÜ ARAŞTIRMALAR SEMPOZYUMU & TANITIM GÜNLERİ 2018
Immune Responses and Mechanisms Against Tumor
Sercan KESKİN, Uygar Halis TAZEBAY, Gamze GÜNGÖR
Moleküler Biyoloji ve Genetik ABD
ÖZET
One of the physiological functions of the immune system is the elimination of tumors and the inhibition of
their growth. The tumor antigens may be products of oncogenes or tumor suppressor genes, mutated cellular
proteins that do not contribute to the malignant phenotype, products of structurally normal molecules that are
displayed abnormally(extremely) or oncogenic viruses. Tumor rejection is mediated primarily by CTLs that recognize
peptides derived from tumor antigens. Initiation of CTL responses against tumor antigens often involves ingestion of
tumor cells or tumor antigens by dendritic cells and presentation of antigens to T cells.
Tumors can escape from immunologic responses by losing antigen expression, blocking expression of MHC
molecules or molecules that act during antigen processing, exerting ligands for T cell inhibitor receptors and
stimulating regulatory T cells, or by secretion of cytokines that suppress immunological responses. Cancer
immunotherapy aims to strengthen the immunological response of a person to tumors by passive or active
administration. Active administration approaches involve the inoculation with tumor antigens or dendritic cells
loaded with tumor antigen and the treatment of cancer diseases with antibodies that block T cell inhibitor receptors.
Anahtar Kelimeler: Tumor, T cell, Immunotherapy, Cancer Immunology.
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