How Does PATZ1 Bind and Inhibit p53, The Master Guardian of The Genome

Thursday, March 22, 2018


MBG Conference Hall



Asst. Prof. Dr. Nazlı KESKİN

OkanUniversity, Faculty of Engineering

Head of Genetics and Bioengineering Department

Dr. Nazlı Keskin received her Bachelor’s degree from Chemical Engineering Department of Marmara University. Her interdisciplinary studies within the fields of chemistry, molecular biology and genetics have later lead to her MSc. and PhD. degrees from Biological Sciences and Bioengineering Program of Sabancı University under the supervision of Prof.Dr. Batu Erman. Since 2015, Dr. Keskin has been working as an assistant professor and since 2016, she is the head of Genetics and Bioengineering Department atOkanUniversity. Her research mainly focuses on identification of novel proteins in the intersection of immunology and cancer biology.



In human cancer, the most common genetic event is the mutation of p53. In addition to this, p53 deficiency results in the accumulation of different types of tumors such as testicular carcinoma, soft tissue sarcoma and lymphoma in mice. The tumor suppressor p53 is a stress responsive, sequence specific transcription factor that regulates genes controlling the cell cycle, senescence and apoptosis. Similar to p53, PATZ1 is a significant modifier of human cancer. Besides being a key transcriptional repressor in lymphocyte development, PATZ1 expression is misregulated in different tumor types such as testicular, colorectal and breast cancers. In this seminar, I will explain how p53 and PATZ1 interacts and what the functional results of this interaction are.  

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