Prof. Dr.
Ramazan ALTUNDAŞ
Chemistry
- Phone
- +90 (262) 605 3092
- raltundas@gtu.edu.tr
- Office
- Chemistry, 152
- Areas of interest
- Enantioslective alkylations, Structurally complex heterocyclic compounds, R&D on API, Syntheses of impurities of drugs, Drug discovery : Anticancer and antimicrobial compounds, Agrochemicals
- Detailed CV
- Projeler-2019.pdf
Papers
1) Asymmetric synthesis of aminocyclooctenecarbonitriles: Cyclooctene β-lactam and hydroxyaminocyclooctene carboxylic precursors
B. Ozturk Aydin, E. Yurtoglu, N. Arcelik, E. Sahin, H. Secen, R. Altundas
Tetrahedron Letters 2019, 60, 284
2) Preparation of arylmagnesium/lithium from aryl bromides and their coupling and substitution reactions in tetrahydrofuran,
O. Gundogdu, R. Altundas, Y. Kara
Applied Organometallic Chemıstry 2017, 31, e3719
3) Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and beta-amino acid derivatives
O. Gundogdu, P. Turhan, A. Kose, R. Altundas, Y. Kara
Tetrahedron:Asymmetry 2017, 28, 1163
4) Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
S. Burmaoğlu, H. Seçinti, E. Mozioglu, Ahmet C. Gören,Ramazan Altundaş, Hasan Seçen
J. Enzyme Inhib. Med. Chem. 2017, 32, 878
5) Oxidation of azidoalkyl furans
M. Z. Kazancioglu, E. A. Kazancioglu, H. Seceen, R. Altundas
Tetrahedron Letters, 2016, 57, 5611
6) Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands
I. Karakaya, S. Karabuga, M. Mart, R. Altundas, S. Ulukanlı
Synthesis, 2016, 48, 1719
7) Cyclic Alkenenitriles: Copper-Catalyzed Deconjugative alpha-Alkylation
X. Yang, D. Nath, J. Morse, C. Ogle, E. Yurtoglu, F. Fleming
J. Org. Chem., 2016, 81, 4098
8) Oxidation of Aminoalkyl and Hyrdoxylaminoalkyl Furans
M. Z. Kazancioglu, E. A. Kazancioglu, H. Secen, R. Altundas
Tetrahedron Letters, 2015, 56, 6994
9) Enantioselective Installation of Quaternary Centers in Cyclic Oxonitriles
Y. Gunes, N. Arcelik, E. Sahin, F. F. Fleming, R. Altundas
Eur. J. Org. Chem., 2015, 6679
10) Novel and Stereospecific Synthesis of (2S)-3-(2,4,5-Trifluorophenyl)propane-1,2-diol from D-Mannitol
D. Aktas, M. Fistikci, O. Gundogdu, H. Secen, M. F. Sahin, R. Altundas, Y. Kara
Helvetica Chimica Acta 2015, 98, 1127
11) Enantiospecific Synthesis of (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Using (S)-Serine as a Chiral Pool
A. Kose, O. Gundogdu, D. Aktas, M. Fistikci, R. Altundas, Y. Kara
Helvetica Chimica Acta 2015, 98, 260
12) Synthesis of quinazoline based chiral ligands and application in the enantioselective addition of phenylacetylene to aldehydes
I. Karakaya, S. Karabuga, R. Altundas, S. Ulukanli
Tetrahedron, 2014, 70, 8385
13) Total Syntheses of Multicaulins via Oxidative Photocyclization of Stilbenes
H. Secinti, S. Burmaoglu, R. Altundas, H. Secen
J. Nat. Product, 2014, 77, 2134
14) Photooxygenation of Azidoalkyl Furans: Catalyst-Free Triazole and New Endoperoxide Rearrangement
E. A. Kazancioglu, M. Z. Kazancioglu, M. Fistikci, H. Secen, R. Altundas
Org. Lett., 2013, 15, 4790
15) Nucleophilic Reactivity of Ethers Against Terminal Epoxides in the Presence of BF3 : A Mechanistic Study
A. Kose, R. Altundas, H. Secen, Y. Kara
Helvetica Chimica Acta 2013, 96, 1325
16) Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid: a synthon for sitagliptin and its derivatives
M. Fistikci, O. Gundogdu, D. Aktas, H. Secen, M. F. Sahin, R. Altundas, Y. Kara
Tetrahedron, 2012, 68, 2607
17) Self-assembled monolayers of fluorene- and nitrofluorene-terminated thiols on polycrystalline gold electrode: Electrochemical and optical properties
Faruk Pak, Kadem Meral, Ramazan Altundaş, Duygu Ekinci.
Journal of Electroanalytical Chemistry, 2011, 654, 20.
18) Enantioselective Synthesis of Cyclic, Quaternary Oxonitriles
Y. Gunes, M. F. Polat, E. Sahin, F. F. Fleming, R. Altundas.
J. Org. Chem., 2010, 75, 7092.
19) Synthesis of Two Alnustone-Like Natural Diarylheptanoids via 4+3 Strategy
S. Burmaoglu, S. Goksu, H. Celik, A. Maras, R. Altundas, H. Secen
Synt. Commun. 2009, 39, 1549.
20) Synthesis and evaluation of ligands for d2-like receptors: the role of common pharmacophoric groups
D. M.N. Sikazwe, N. T. Nkansah, R. Altundas, X. Y. Zhu, B. L. Roth, V. Setola, S. Y. Ablordeppey
Bioorg. Med. Chem. 2009, 17, 1716.
21) A short and efficient synthesis of cytotoxic 3-isopropylnaphthalene-1,2-dione via 3-hydroxy-2-naphthoic acid
S. Burmaoglu, R. Altundas, H. Secen
Arkivoc. 2008, 269
22) Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1(4-fluorophenyl)butan-1-one
S. Y. Ablordeppey, R. Altundas, B. Bricker,X.Y. Zhu, E. V. K. S Kumar, T. Jackson, A. Khan, B. L. Roth
Bioorg. Med. Chem. 2008, 16, 7291
23) A novel one-pot conversion of allyl alcohols into primary allyl halides mediated by acetyl halide
N. Kishali, M. F. Polat, R. Altundas, R, Y. Kara
Helvetica Chemica Acta, 2008, 91, 67
24) An efficient synthesis of (R)-GABOB and of (+/-)-GABOB
E. Sahin, N. Kishali, L. Kelebekli, E. Mete, H. Secen, R. Altundas, Y. Kara
Organic Preperations and Procedures International, 2007, 39, 509
25) Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+ like species
M. L.-Engleston, R. Altundas, J. Xia, D.M. N. Sikazwe, P. Fan, Q. Yang, S. Li, W. Zhang, X. Zhu, A. W. Schimidt, M. V. Fraley, A. Shrihkande, A. Villalobos, R. F. Borne, S. Y. Ablordeppey
J. Med. Chem. 2004, 47, 497 2006
26) A Synthetic route to anandamide analogues carrying a substituent at the terminal carbon and an acetylene group in the end pentyl chain
Ramazan Altundas, Anu mahadevan and Raj K. Razdan
Tetrahedron Letters, 2004, 45 5449
27) Studies on base-catalyzed rearrangement of Bicyclic Endoperoxide
Ebru Mete, Ramazan Altundas, Hasan Secen, Metin Balci
Turk. J. Chem., 2003, 27, 145
28) Di--methane rearrangement of disubstituted Benzobarrelene and Benzonorbornadiene Derivatives
Ramazan Altundas, Nermin S. Unal, Kutalmis Guven, Orhan Uzun, Metin Balci
Eur. J. Org. Chem., 2002, 526
29) Cyclic Alkenenitriles: Chemoselective Oxonitrile Cyclizations
Fraser F. Fleming, Lee A. Funk, Ramazan Altundas, and Vaqar Sharief
J. Org. Chem., 2002, 67, 9414 – 9416
30) Heterogeneous Oxidation of [2.2.1] Bridged Bicyclic Alkenes with KMnO-CuSO4.5H2O: An Alternative Ozonolysis
Suleyman Goksu, Ramazan Altundas, Yasar Sutbeyaz
Synthetic Communications, 2000, 30, 1615
31) Electrochemical synthesis of 2-amino-3-cyano-4-phenyl thiophene polymer and studies on its electronic properties
Duygu Ekinci, Ramazan Altundas and Umit Demir
Journal of Electroanalytical Chemistry, 2000, 484, 101
32) Photooxygenation of 2-amino-3-cyano-4,5,6,7- tetrahydrobenzo[b]thiophene
Ramazan Altundas, Mariusz Krawiec,William H. Watson, Metin Balci
Journal of Chemical Crystallography, 1997, 27, 645
33) Di--methane Photorearrangement of 2,3-disubstitutedbenzobarrelene: The Effect of Substituents of
Opposite Polarity on Regioselectivity
Ramazan Altundas and Metin Balci
J. Aust. Chem., 1997, 50, 787-793
34) Photooxygenation of an Enol Ether: Synthesis of exo- and endo-3,4-Dioxa-2,5-dimethoxy-7,8-
benzo{4.2.2.02.5]deca-7,9-diene and its Chemical Transformations
Ramazan Altundas and Metin Balci
Tetrahedron, 1993, 49, 6521
Patents
1) TR2012/01883, Sitagliptin için kiral hammadde hazırlama yöntemi
2) TR2012/07905, Sitagliptin için kiral hammadde hazırlama yöntemi
3) PCT/TR2018/050761, A Process for Preparation of 3-(4-Phenoxyphenyl)-1h-Pyrazolo[3,4-D ]Pyrimidin-4- Amine
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Third Cycle (Doctoral): Atatürk Üniversitesi
- Second Cycle (Master's): Atatürk Üniversitesi
- First Cycle (Undergraduate): Atatürk Üniversitesi
Scientist, Organix Inc. Woburn, Boston
Postdoc. Florida A&M University, Tallahassee, Florida
Postdoc. Duquesne University, Pitsburgh, PA