Prof. Dr. Ramazan ALTUNDAŞ
Chemistry

Ramazan ALTUNDAŞ
Phone
+90 (262) 605 3092
Email
raltundasgtu.edu.tr
Office
Chemical Engineering, 152
Areas of interest
Enantioslective alkylations, Structurally complex heterocyclic compounds, R&D on API, Syntheses of impurities of drugs, Drug discovery : Anticancer and antimicrobial compounds, Agrochemicals
Detailed CV
Projeler-2019.pdf

Papers

1) Asymmetric synthesis of aminocyclooctenecarbonitriles: Cyclooctene β-lactam and hydroxyaminocyclooctene carboxylic precursors

B. Ozturk Aydin, E. Yurtoglu, N. Arcelik, E. Sahin, H. Secen, R. Altundas
Tetrahedron Letters 2019, 60, 284

2) Preparation of arylmagnesium/lithium from aryl bromides and their coupling and substitution reactions in tetrahydrofuran,

O. Gundogdu, R. Altundas, Y. Kara

Applied Organometallic Chemıstry 2017, 31, e3719

3) Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and beta-amino acid derivatives

O. Gundogdu, P. Turhan, A. Kose, R. Altundas, Y. Kara

Tetrahedron:Asymmetry 2017, 28, 1163

4) Syntheses and evaluation of multicaulin and miltirone-like compounds as antituberculosis agents
S. Burmaoğlu, H. Seçinti, E. Mozioglu, Ahmet C. Gören,Ramazan Altundaş, Hasan Seçen

J. Enzyme Inhib. Med. Chem. 2017, 32, 878

5) Oxidation of azidoalkyl furans
M. Z. Kazancioglu, E. A. Kazancioglu, H. Seceen, R. Altundas

Tetrahedron Letters, 2016, 57, 5611

6) Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands

I. Karakaya, S. Karabuga, M. Mart, R. Altundas, S. Ulukanlı

Synthesis, 2016, 48, 1719

7) Cyclic Alkenenitriles: Copper-Catalyzed Deconjugative alpha-Alkylation

X. Yang, D. Nath, J. Morse, C. Ogle, E. Yurtoglu, F. Fleming

J. Org. Chem., 2016, 81, 4098

8) Oxidation of Aminoalkyl and Hyrdoxylaminoalkyl Furans

M. Z. Kazancioglu, E. A. Kazancioglu, H. Secen, R. Altundas

Tetrahedron Letters, 2015, 56, 6994

9) Enantioselective Installation of Quaternary Centers in Cyclic Oxonitriles

Y. Gunes, N. Arcelik, E. Sahin, F. F. Fleming, R. Altundas

Eur. J. Org. Chem., 2015, 6679

10) Novel and Stereospecific Synthesis of (2S)-3-(2,4,5-Trifluorophenyl)propane-1,2-diol from D-Mannitol

D. Aktas, M. Fistikci, O. Gundogdu, H. Secen, M. F. Sahin, R. Altundas, Y. Kara

Helvetica Chimica Acta 2015, 98, 1127

11) Enantiospecific Synthesis of (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Using (S)-Serine as a Chiral Pool

A. Kose, O. Gundogdu, D. Aktas, M. Fistikci, R. Altundas, Y. Kara

Helvetica Chimica Acta 2015, 98, 260

12) Synthesis of quinazoline based chiral ligands and application in the enantioselective addition of phenylacetylene to aldehydes

I. Karakaya, S. Karabuga, R. Altundas, S. Ulukanli

Tetrahedron, 2014, 70, 8385

13) Total Syntheses of Multicaulins via Oxidative Photocyclization of Stilbenes

H. Secinti, S. Burmaoglu, R. Altundas, H. Secen

J. Nat. Product, 2014, 77, 2134

14) Photooxygenation of Azidoalkyl Furans: Catalyst-Free Triazole and New Endoperoxide Rearrangement

E. A. Kazancioglu, M. Z. Kazancioglu, M. Fistikci, H. Secen, R. Altundas

Org. Lett., 2013, 15, 4790

15) Nucleophilic Reactivity of Ethers Against Terminal Epoxides in the Presence of BF3 : A Mechanistic Study

A. Kose, R. Altundas, H. Secen, Y. Kara

Helvetica Chimica Acta 2013, 96, 1325

16) Novel and enantioselective syntheses of (R)- and (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanoic acid: a synthon for sitagliptin and its derivatives

M. Fistikci, O. Gundogdu, D. Aktas, H. Secen, M. F. Sahin, R. Altundas, Y. Kara

Tetrahedron, 2012, 68, 2607

17) Self-assembled monolayers of fluorene- and nitrofluorene-terminated thiols on polycrystalline gold electrode: Electrochemical and optical properties

Faruk Pak, Kadem Meral, Ramazan Altundaş, Duygu Ekinci.

Journal of Electroanalytical Chemistry, 2011, 654, 20.

18) Enantioselective Synthesis of Cyclic, Quaternary Oxonitriles

Y. Gunes, M. F. Polat, E. Sahin, F. F. Fleming, R. Altundas.

J. Org. Chem., 2010, 75, 7092.

19) Synthesis of Two Alnustone-Like Natural Diarylheptanoids via 4+3 Strategy

S. Burmaoglu, S. Goksu, H. Celik, A. Maras, R. Altundas, H. Secen

Synt. Commun. 2009, 39, 1549.

20) Synthesis and evaluation of ligands for d2-like receptors: the role of common pharmacophoric groups

D. M.N. Sikazwe, N. T. Nkansah, R. Altundas, X. Y. Zhu, B. L. Roth, V. Setola, S. Y. Ablordeppey

Bioorg. Med. Chem. 2009, 17, 1716.

21) A short and efficient synthesis of cytotoxic 3-isopropylnaphthalene-1,2-dione via 3-hydroxy-2-naphthoic acid

S. Burmaoglu, R. Altundas, H. Secen

Arkivoc. 2008, 269

22) Identification of a butyrophenone analog as a potential atypical antipsychotic agent: 4-[4-(4-Chlorophenyl)-1,4-diazepan-1-yl]-1(4-fluorophenyl)butan-1-one

S. Y. Ablordeppey, R. Altundas, B. Bricker,X.Y. Zhu, E. V. K. S Kumar, T. Jackson, A. Khan, B. L. Roth

Bioorg. Med. Chem. 2008, 16, 7291

23) A novel one-pot conversion of allyl alcohols into primary allyl halides mediated by acetyl halide

N. Kishali, M. F. Polat, R. Altundas, R, Y. Kara

Helvetica Chemica Acta, 2008, 91, 67

24) An efficient synthesis of (R)-GABOB and of (+/-)-GABOB

E. Sahin, N. Kishali, L. Kelebekli, E. Mete, H. Secen, R. Altundas, Y. Kara

Organic Preperations and Procedures International, 2007, 39, 509

25) Design, synthesis, and evaluation of metabolism-based analogues of haloperidol incapable of forming MPP+ like species

M. L.-Engleston, R. Altundas, J. Xia, D.M. N. Sikazwe, P. Fan, Q. Yang, S. Li, W. Zhang, X. Zhu, A. W. Schimidt, M. V. Fraley, A. Shrihkande, A. Villalobos, R. F. Borne, S. Y. Ablordeppey

J. Med. Chem. 2004, 47, 497 2006

26) A Synthetic route to anandamide analogues carrying a substituent at the terminal carbon and an acetylene group in the end pentyl chain

Ramazan Altundas, Anu mahadevan and Raj K. Razdan

Tetrahedron Letters, 2004, 45 5449

27) Studies on base-catalyzed rearrangement of Bicyclic Endoperoxide

Ebru Mete, Ramazan Altundas, Hasan Secen, Metin Balci

Turk. J. Chem., 2003, 27, 145

28) Di--methane rearrangement of disubstituted Benzobarrelene and Benzonorbornadiene Derivatives

Ramazan Altundas, Nermin S. Unal, Kutalmis Guven, Orhan Uzun, Metin Balci

Eur. J. Org. Chem., 2002, 526

29) Cyclic Alkenenitriles: Chemoselective Oxonitrile Cyclizations

Fraser F. Fleming, Lee A. Funk, Ramazan Altundas, and Vaqar Sharief

J. Org. Chem., 2002, 67, 9414 – 9416

30) Heterogeneous Oxidation of [2.2.1] Bridged Bicyclic Alkenes with KMnO-CuSO4.5H2O: An Alternative Ozonolysis

Suleyman Goksu, Ramazan Altundas, Yasar Sutbeyaz

Synthetic Communications, 2000, 30, 1615

31) Electrochemical synthesis of 2-amino-3-cyano-4-phenyl thiophene polymer and studies on its electronic properties

Duygu Ekinci, Ramazan Altundas and Umit Demir

Journal of Electroanalytical Chemistry, 2000, 484, 101

32) Photooxygenation of 2-amino-3-cyano-4,5,6,7- tetrahydrobenzo[b]thiophene

Ramazan Altundas, Mariusz Krawiec,William H. Watson, Metin Balci

Journal of Chemical Crystallography, 1997, 27, 645

33) Di--methane Photorearrangement of 2,3-disubstitutedbenzobarrelene: The Effect of Substituents of
Opposite Polarity on Regioselectivity

Ramazan Altundas and Metin Balci

J. Aust. Chem., 1997, 50, 787-793

34) Photooxygenation of an Enol Ether: Synthesis of exo- and endo-3,4-Dioxa-2,5-dimethoxy-7,8-
benzo{4.2.2.02.5]deca-7,9-diene and its Chemical Transformations

Ramazan Altundas and Metin Balci

Tetrahedron, 1993, 49, 6521

Patents

1) TR2012/01883, Sitagliptin için kiral hammadde hazırlama yöntemi


2) TR2012/07905, Sitagliptin için kiral hammadde hazırlama yöntemi


3) PCT/TR2018/050761, A Process for Preparation of 3-(4-Phenoxyphenyl)-1h-Pyrazolo[3,4-D ]Pyrimidin-4- Amine

  • Third Cycle (Doctoral): Atatürk Üniversitesi


  • Second Cycle (Master's): Atatürk Üniversitesi
  • First Cycle (Undergraduate): Atatürk Üniversitesi
Visiting Scientist, University of North Carolina, Chapel Hill, NC

Scientist, Organix Inc. Woburn, Boston

Postdoc. Florida A&M University, Tallahassee, Florida

Postdoc. Duquesne University, Pitsburgh, PA
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