Prof. Dr. Nuri ÖZTÜRK
Moleküler Biyoloji ve Genetik

Nuri ÖZTÜRK
Telefon
(262) 605-2521
E-Posta
nuriozturkgtu.edu.tr
Web sayfası
https://sites.google.com/site/biologicalclocklaboratory/
Ofis
C Blok, 110
Çalışma alanları
CRİSPR-tabanlı genom düzenlemesi ve biyoteknolojik uygulamaları, Biyolojik saat ve insan sağlığı ilişkisi (Kanser ve Kök Hücre Farklılaşması), Işık tarafından biyolojik saatin düzenlenmesi mekanizması

1.Ozcelik G, Koca MS, Sunbul B, Yilmaz-Atay F, Demirhan F, Tiryaki B, Cilenk B, Selvi S, Ozturk N (2024) Interactions of Drosophila Cryptochrome.Photochem Photobiol. 2024;00:1-20. doi:10.1111/php.1391

2.Surme S, Ergun C, Gul S, Akyel YK, Gu ZMl, Ozcan O, Ipek OS, Akarlar BA, Ozlu N, Taskin AC, Turkay M, Goren AC, Baris I, Ozturk N; Guzel M, Aydin C, Okyar A, Kavakli (2023) TW68, cryptochromes stabilizer, regulates fasting blood glucose levels in diabetic ob/ob and high fat-diet-induced obese mice.Biochemical Pharmacology, Volume 218, 2023, 115896 (2023)

3.Gul S, Akyel YK, Gul ZM, Isin S, Ozcan O, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Akarlar BA, Ozlu N, Ozturk N, Ozturk N, Ünal DO, Guzel M, Turkay M, Okyar; Kavakli IH Discovery of a small molecule that selectively destabilizes Cryptochrome 1 and enhances life span in p53 knockout mice. Nature Communications 13, 6742 (2022). https://doi.org/10.1038/s41467-022-34582-1

4.Kavakli IH, Ozturk N, Baris I (2022) Protein interaction networks of the mammalian core clock proteins. Advances in protein chemistry and structural biology 131, 207-233

5. Ozturk, N. (2022), Light-dependent reactions of animal circadian photoreceptor cryptochrome. FEBS J, 289: 6622-6639. https://doi.org/10.1111/febs.16273

6.Gul H, Selvi S, Yilmaz F, Ozcelik G, Olfaz-Aslan S, Yazan S, Tiryaki B, Gul S, Yurtseven A, Kavakli IH, Ozlu N, Ozturk N. (2022) Proteome analysis of the circadian clock protein PERIOD2. Proteins:Structure, Function, and Bioinformatics 90 (6), 1315- 1330

7. Gul S., Rahim, F, Isin, S, Fatma Yilmaz, Ozturk N, Turkay M, Kavakli IH (2021) Structure-based design and classifications of small molecules regulating the circadian rhythm period. Sci Rep 11, 18510

8. Gul S, Akyel YK, Gu Z.M.l, Isin S, Korkmaz T, Selvi S, Danis I, Ipek OS, Aygenli F, Taskin AC, Ozturk N, Ozturk N, Unal DO, Guzel M, Turkay M, Okyar A, Kavakli IH. (2021) Discovery of a small molecule that selectively destabilizes cryptochrome 1 and enhances life span in p53 knockout mice. bioRxiv, 2021.2007.2021.453206

9. Emisoglu-Kulahli H, Gul S, Morgil H, Ozcan O, Aygenli F, Selvi S. Kavakli IH, Ozturk N. (2021) Transcriptome analysis of the circadian clock gene BMAL1 deletion with opposite carcinogenic effects. Functional and Integrative genomics 21, 1–16

10. Doruk YU, Yarparvar D, Akyel YK, Gul S, Taskin AC, Yilmaz F, Baris I, Ozturk N, Türkay M, Ozturk N, Okyar A, Kavakli IH (2020) A CLOCK-binding small molecule disrupts the interaction between CLOCK and BMAL1 and enhances circadian rhythm amplitude. J. Biol. Chem. 295 (11), 3518-3531

11. Dikbas UM, Tardu M,Canturk A,Gul S, Özçelik G, Baris I, Ozturk N, Kavakli IH (2019) Identification and characterization of a new class of (6-4) photolyase from Vibrio cholerae. Biochemistry 56(43), 4352-4360

12. Cavga AD, Tardu M., Korkmaz T, Keskin O, Ozturk N, Gursoy A, Kavakli IH. Funct Integr Genomics (2019) Cryptochrome deletion in p53 mutant mice enhances apoptotic and anti-tumorigenic responses to UV damage at the transcriptome level. Functional & integrative genomics 19 (5), 729-742

13. Kavakli, I.H., Ozturk, N., and Gul, S. (2019). DNA repair by photolyases. Advances in protein chemistry and structural biology 115, 1-19.

14. T Korkmaz, F Aygenli, H Emisoglu, G Ozcelik, A Canturk, S Yilmaz, Ozturk N (2018) Opposite Carcinogenic Effects of Circadian Clock Gene BMAL1. Scientific reports 8 (1), 16023

15. N. Ozturk (2017) Phylogenetic and Functional Classification of the Photolyase/Cryptochrome Family. Photochemistry and Photobiology 93 (1), 104-111

16. A. Sancar, L.A Lindsey-Boltz, S. Gaddameedhi, C.P. Selby, R. Ye, Y.Y. Chiou, M.G. Kemp, J. Hu, J.H. Lee, N. Ozturk (2015) Circadian Clock, Cancer, and Chemotherapy. Biochemistry 54(2):110-23

17. N. Ozturk, C. P. Selby, D. Zhong, A. Sancar (2014) Mechanism of Photosignaling by Drosophila Cryptochrome ROLE OF THE REDOX STATUS OF THE FLAVIN CHROMOPHORE, J Biol Chem. 289: 4634-4642.

18. N. Ozturk, S. J. VanVickle-Chavez, L. Akileswaran, R. N. Van Gelder, A. Sancar (2013) Ramshackle (Brwd3) Promotes Light-induced Ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 Complex. Proc Natl Acad Sci U S A. 110: 4980-4985.

19. I. Ozkan-Dagliyan, Y. Y. Chiou, R. Ye, B. H. Hassan, N. Ozturk, A. Sancar (2013) Formation and Characterization of Plant Cryptochrome Photobodies in Mammalian Cells. J Biol Chem. 288:23244-23251.

20. G. Yildiz, A. Arslan-Ergul, S. Bagislar, O. Konu, H. Yuzugullu, O. Gursoy-Yuzugullu, N. Ozturk, C. Ozen, H. Ozdag, E. Erdal, S. Karademir, O. Sagol, D. Mizrak, H. Bozkaya, H. G. Ilk, O. Ilk, B. Bilen, R. Cetin-Atalay, N. Akar, M. Ozturk (2013) Genome-Wide Transcriptional Reorganization Associated with Senescence-to-Immortality Switch during Human Hepatocellular Carcinogenesis. PLoS ONE 8(5): e64016.

21. A. S. Rivera, N. Ozturk, B. Fahey, D. C. Plachetzki, B. M. Degnan, A. Sancar, T. H. Oakley (2012) Blue light-receptive Cryptochrome is expressed in a sponge eye lacking neurons and opsin. J Exp Biol. 215: 1278-1286.

22. S. Gaddameedhi, J. T. Reardon, R. Ye, N. Ozturk, A. Sancar (2012) Effect of circadian clock mutations on DNA damage response in mammalian cells. Cell Cycle 11: 3481-3491.

23. J. H. Lee, S. Gaddameedhi, N. Ozturk, R. Ye, A. Sancar (2013) DNA damage-specific control of cell death by cryptochrome in p53 mutant Ras-transformed cells. Cancer Res. 73: 785-791.

24. N. Ozturk, C. P. Selby, Y. Annayev, D. Zhong, A. Sancar (2011) Reaction Mechanism of Drosophila Cryptochrome. Proc Natl Acad Sci U S A. 108: 516-521.

25. R. Ye, C. P. Selby, N. Ozturk, Y. Annayev, A. Sancar (2011) Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock. J Biol Chem. 286: 25891-25902.

26. A. Sancar, L. A. Lindsey-Boltz, T. H. Kang, J. T. Reardon, J. H. Lee, N. Ozturk. (2010) Circadian clock control of the cellular response to DNA damage. FEBS Lett. 584: 2618-2625.

27. E. Kavak, A. Najafov, N. Ozturk, T. Seker, K. Cavusoglu, T. Aslan, A. D. Duru, T. Saygili, G. Hoxhaj, M. C. Hiz, D. O. Unal, N. Birgul-Iyison, M. Ozturk, A. Koman (2010) Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets. Cell Signal. 22: 1523-1535.

28. N. Ozturk, J. H. Lee, S. Gaddameedhi, A. Sancar (2009) Loss of cryptochrome reduces cancer risk in p53 mutant mice. Proc Natl Acad Sci U S A. 106: 2841-2846.

29. N. Ozturk, C. P. Selby, S. H. Song, R. Ye, C. Tan, Y. T. Kao, D. Zhong, A. Sancar (2009) Comparative photochemistry of animal type 1 and type 4 cryptochromes. Biochemistry 48: 8585-8593.

30. H. Yuzugullu, K. Benhaj, N. Ozturk, S. Senturk, E. Celik, A. Toylu, N. Tasdemir, M. Yilmaz, E. Erdal, K. C. Akcali, N. Atabey, M. Ozturk (2009) Canonical Wnt signaling is antagonized by noncanonical Wnt5a in hepatocellular carcinoma cells. Mol Cancer. 8: 90.

31. N. Ozturk, Y. T. Kao, C. P. Selby, I. H. Kavakli, C. L. Partch, D. Zhong, A. Sancar (2008) Purification and characterization of a type III photolyase from Caulobacter crescentus. Biochemistry 47: 10255-10261.

32. Y. T. Kao, C. Tan, S. H. Song, N. Ozturk, J. Li, L. Wang, A. Sancar, D. Zhong (2008) Ultrafast dynamics and anionic active states of the flavin cofactor in cryptochrome and photolyase. J Am Chem Soc. 130: 7695-7701.

33. N. Ozturk, S. H. Song, C. P. Selby, A. Sancar (2008) Animal type 1 cryptochromes. Analysis of the redox state of the flavin cofactor by site-directed mutagenesis. J Biol Chem. 283: 3256-3263.

34. N. Ozturk, S. H. Song, S. Ozgur, C. P. Selby, L. Morrison, C. Partch, D. Zhong, A. Sancar (2007) Structure and function of animal cryptochromes. Cold Spring Harb Symp Quant Biol. 72:119-131.

35. S. H. Song, N. Ozturk, T. R. Denaro, N. O. Arat, Y. T. Kao, H. Zhu, D. Zhong, S. M. Reppert, A. Sancar (2007) Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J Biol Chem. 282: 17608-17612.

36. N. Ozturk, E. Erdal, M. Mumcuoglu, K. C. Akcali, O. Yalcin, S. Senturk, A. Arslan-Ergul, B. Gur, I. Yulug, R. Cetin-Atalay, C. Yakicier, T. Yagci, M. Tez, M. Ozturk (2006) Reprogramming of replicative senescence in hepatocellular carcinoma-derived cells. Proc Natl Acad Sci U S A. 103: 2178-2183.

37. E. Erdal, N. Ozturk, T. Cagatay, E. Eksioglu-Demiralp, M. Ozturk (2005) Lithium-mediated downregulation of PKB/Akt and cyclin E with growth inhibition in hepatocellular carcinoma cells. Int J Cancer. 115: 903-10.

MEHMET SERDAR KOCA (2023) Identification of Molecules that Affect CRY1-PER2 Interaction

ŞEYMA YAZAN (2023) Exploring period2 interactome

KEVSER ÇİLENK (2022) Exploring Novel BMAL1 Interactıons. MSc. Thesis

FERİDE DEMİRHAN (2022) Investigation of Drosophila Cryptochrome İnteractions, MSc. Thesis

HÜSEYİN GÜL (2022) Interactome Mapping of BMAL1 and PER2 by Proximıity-dependent labeling, PhD. Thesis

BARIŞ CAN ÜLKÜ (2022) Effect of PER2 Interactome on PER2 stability, MSc. Thesis

SATI PALTACI (2021) Analysis of Structural Changes in Cryptochrome Protein by Fluorescence Energy Transfer (FRET), MSc. Thesis

SABA SELVI (2021) Exploring Novel CRY1 Interactions, MSc. Thesis

HANDAN EMİŞOĞLU-KÜLAHLI (2021) Connection between The Circadian Clock and Cellular Stress in Cancer Cells. PhD. Thesis.

FATMA YILMAZ (2020) Investigation of protein associated with circadian rhythms using CRISPR-CAS9 technology and proximity labeling, MSc. Thesis.

SENANUR OLFAZ (2020) Exploring the interactome of recombinant CRY1 protein by proximity labeling, MSc. Thesis.

BÜŞRA ACAR (2019) The Effect of Small Molecule Modulators of Cryptochrome on Apoptosıs, MSc. Thesis.

TUBA KORKMAZ (2019) Systematic Analysis of the Relationship between Biological Clock and Cancer Development, PhD. Thesis

FATİH AYGENLİ (2019) Probing Clock Proteins in Live Cells by Fluorescence, MSc. Thesis.

ASENA CANTÜRK (2019) Comparison of Screening Methods for CRISPR/CAS9-induced Mutations, MSc. Thesis

FERAYE HATİCE CANBAZ (2018) Mapping the Light-dependent Interaction Sites on Drosophila Biological Clock Photoreceptor, MSc. Thesis.

BİHTER MURATOĞLU (2018) Flexibility of C-terminus of cryptochrome protein for photoreceptor function, MSc. Thesis

MELTEM AŞICIOĞLU (2018) Investigation of the effect of circadian clock disruption on DNA methylation, MSc. Thesis

KAAN CAN ÖMEROĞLU (2017) Role of RTCB protein under stress conditions, MSc. Thesis

GÖZDE ÖZÇELİK (2016) Development of optogenetic tools based on cryptochrome protein, MSc. Thesis

  • Doktora: Bilkent Üniversitesi
  • Yüksek lisans: Bilkent Üniversitesi
  • Lisans: İstanbul Üniversitesi
Ödüller:
TÜBİTAK Proje Performans Ödülü (2020)
TÜBA-GEBİP (2015)
TÜBİTAK2232- Doktora sonrası Yurda Dönüş Programı Bursu (2014)
UNC Doktora Sonrası Araştırma Mükemmeliyet Ödülü (2011)
Bilkent Üniversitesi Bursu (1998-2006)

Diğer Tecrübeler:
Doktora Sonrası Araştırmacı (2006-2012) Biyofizik ve Biyokimya Bölümü, Tıp Fakültesi, University of North Carolina at Chapel Hill,School of Medicine, NC, A.B.D

Yard. Doç. (2012-2014) Biyofizik ve Biyokimya Bölümü, Tıp Fakültesi, University of North Carolina at Chapel Hill, School of Medicine, NC, A.B.D
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