Prof. Dr. Uygar Halis TAZEBAY
Moleküler Biyoloji ve Genetik

Uygar Halis TAZEBAY
Telefon
(262) 6052522
E-Posta
tazebaygtu.edu.tr
Ofis
C2 Blok, 210
Çalışma alanları
İşlevsel genombilim, Hücre bölünmesinin moleküler kontrolü, Taşıyıcı zar proteinleri ve kodlayıcı genlerin transkripsiyon düzeyinde kontrolü.
Detaylı özgeçmiş
Tazebay CV TR.pdf

Telkoparan P, Erkek S, Yaman E, Alotaibi H, Bayik D, Tazebay UH. Coiled-coil domain-containing protein 124 is a novel centrosome and midbody protein that interacts with the Ras-guanine nucleotide exchange factor 1B and is involved in cytokinesis. PLoS One, Vol. 8(7), July 2013, e69289.

Akturk M, Sargin-Oruc A, Danisman N, Erkek S, Buyukkagnici U, Unlu E, Tazebay UH. Na+/I- symporter and type 3 iodothyronine deiodinase gene expression in amniotic membrane and placenta and its relationship to maternal thyroid hormones. Biological Trace Element Research, Vol. 154(3), July 2013, 338-344.

Cevik SI, Keskin N, Belkaya S, Ozlu MI, Deniz E, Tazebay UH, Erman B. CD81 interacts with the T cell receptor to suppress signaling. PLoS One, Vol. 7(11), November 2012, e50396.

Yavas S, Erdogan M, Gurel K, Ilday FÖ, Burak Eldeniz Y, Tazebay UH. Fiber laser microscope system for femtosecond photodisruption of biological samples. Biomedical Optics Express, Vol. 3(3), March 2012, 605-611.

Erdogan M, Oktem B, Kalaycioglu H, Yavas S, Mukhopadhyay P, Aykac Y, Tazebay UH, Ilday FÖ. Texturing of titanium (Ti6Al4V) medical implant surfaces with MHz-repetition-rate femtosecond and picosecond Yb-doped fiber lasers. Optics Express, Vol. 19(11), May 2011, 10986-10996.

Alotaibi H, Yaman E, Salvatore D, Di Dato V, Telkoparan P, Di Lauro R, Tazebay UH. Intronic elements in the Na+/I- symporter gene (NIS) interact with retinoic acid receptors and mediate initiation of transcription. Nucleic Acids Research, Vol. 38(10), June 2010, 3172-3185.

Mumcuoglu M, Bagislar S, Yuzugullu H, Alotaibi H, Senturk S, Telkoparan P, Gur-Dedeoglu B, Cingoz B, Bozkurt B, Tazebay UH, Yulug IG, Akcali KC, Ozturk M. The ability to generate senescent progeny as a mechanism underlying breast cancer cell heterogeneity. PLoS One, Vol. 24;5(6). June 2010, E-publication: e11288.

Yaman E, Gasper R, Koerner C, Wittinghofer A, Tazebay UH. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS Journal, Vol. 276(16), August 2009, 4607-4616.

Tuncel M, Aydın D, Yaman E, Tazebay UH, Güç D, Doğan AL, Taşbasan B, Uğur Ö. The comparative effects of gene modulators on thyroid specific genes and radioiodine uptake. Cancer Biotherapy and Radiopharmaceuticals, Vol. 22(3), April 2007, 281-288.

Alotaibi H, Yaman-Çankaya E, Demirpençe E, Tazebay UH. Unliganded estrogen receptor-alpha activates transcription of the mammary gland Na+/I- symporter gene. Biochemical and Biophysical Research Communications, Vol. 345(4), July 2006, 1487-1496.

Tavoularis SN, Tazebay UH, Diallinas G, Rosa A, Scazzocchio C, Sophianopoulou V. Mutational analysis of the major proline transporter of (PrnB) of Aspergillus nidulans. Molecular Membrane Biology, Vol. 20(4), October-December 2003, 285-297.

Tazebay UH, Wapnir IL, Levy O, Dohan O, Zuckier LS, Zhao QH, Deng HF, Amenta PS, Fineberg S, Pestell RG, Carrasco N. The mammary gland iodide transporter is expressed during lactation and in breast cancer.” Nature Medicine, Vol. 6(8), August 2000, 871-878.

Tazebay UH, Sophianopoulou V, Scazzocchio C, Diallinas G. The gene encoding the major proline transporter of Aspergillus nidulans is upregulated during conidiospore germination and in response to proline induction and amino acid starvation.” Molecular Microbiology, Vol. 24(1), April 1997, 105-117.

Tazebay UH, Sophianopoulou V, Cubro B, Scazzocchio C, Diallinas G. Post-transcriptional control and kinetic characterization of proline transport in germinating conidiospores of Aspergillus nidulans.” FEMS Microbiology Letters, 132(1), October 1995, 27-37.

Tazebay UH, Sophianopoulou V, Rosa A, Scazzocchio C, Diallinas G. Structure-function analysis of the proline permease (PrnB) of the filamentous fungus Aspergillus nidulans.” Folia Microbiologica, Vol. 39(6), October 1994, 551.

Directed Ph.D.Thesis / Doktora Tezleri:

1. Hani ALOTAIBI, Ph.D., "Identification of novel genetic elements controlling transcriptional regulation of the human Na+/I- symporter (NIS) gene", 1/2001 – 7/2006

2. Elif YAMAN, Ph.D., "Functional identification of RasGEF1 family of exchange factors as activators of Rap2, and as interacting partners of Ccdc-124", 9/2003 – 12/2009

3. Mutlu ERDOĞAN, Ph.D., "Application of Femtosecond Fiber Lasers for Manipulating Neuronal Dynamics", 9/2007 – 2/2014

4. Pelin TELKOPARAN, Ph.D., "Regulation of RasGEF1 (Ras-Guanine Nucleotide Exchange Factor-1) family of proteins and their involvement in control of Rap2 GTP-binding protein modulated signal transduction", 9/2009 – 06/2013


Directed M.Sc. Thesis / Yönettiği Yüksek Lisans Çalışmaları:

1. Sinem GÜL, MSc., "CRISPR/Cas9 yöntemi aracılığı ile İnsan Ccdc124 geni delesyonunun hücre bölünmesi üzerine etkileri", 1/2013 – 7/2015

2. Özge ARSLAN, MSc., "Coiled-coil domain-containing protein-124 (Ccdc124) artışının hücre fizyolojisine ve bölünmesine etkileri", 1/2013 – 1/2015

3. Irem GÜRBÜZ, MSc., "Monoclonal antibody production for Coiled-coil domain containing-124 (Ccdc-124) and its molecular characterization", 9/2008 – 8/2010

4. Serap ERKEK, MSc., "Hanein-1, a novel conserved eukaryotic protein ubiquitously expressed in human tissues", 9/2006 – 8/2008

5. Esra KARAKÖSE, MSc., "Functional characterization of Loc115098: A novel gene conserved in eukaryotic genomes", 9/2004 – 1/2007

6. Neriman Tuba GÜLBAĞCI, MSc., "Estradiol dependent transcriptional regulation of hNIS", 9/2000 – 8/2002

  • Doktora: 1998-University of Paris 11.
    Analyse mutationelle et étude de la regulation du gène prnB impliqué dans le transport de la proline chez Aspergillus nidulans (Mutational analysis and study on regulation of gene prnB involved in proline uptake in Aspergillus nidulans). Defended on the 10th of July, 1998.
    Thesis supervisor: Prof. Dr. Claudio SCAZZOCCHIO
  • Yüksek lisans: 1994-University of Paris 11.
    Analyse du structure/fonction du gène prnB impliqué dans le transport de la proline chez Aspergillus nidulans (Structure/function analysis of gene prnB involved in proline uptake in Aspergillus nidulans). Defended on the 9th of September, 1994.
    Thesis supervisor: Prof. Dr. Claudio SCAZZOCCHIO
  • Lisans: Ortadoğu Teknik Üniversitesi, Biyoloji Bölümü (1993)
    Middle East Technical University, Department of Biology (1993)
Doktora sonrası çalışmaları:
1998-2000, Araştırma Görevlisi, Moleküler Farmakoloji Bölümü, Albert Einstein Tıp Fakültesi, Bronx, New York, USA.

Patentleri:
"Methods for the Diagnosis and Treatment of Breast Cancer."
United States Patent No. 6,821,725. Patent filing date: Mar. 7, 2000; Patent date: Nov. 23, 2004. Inventors: Drs. Nancy CARRASCO (New York, USA), Orsolya DOHAN (New York, USA), Uygar H. TAZEBAY (Bilkent, Turkey), Irene L. WAPNIR (Stanford, USA).

"Methods for the Diagnosis and Treatment of Breast Cancer."
United States Patent No. 7,303,740. Patent filing date: Oct. 8, 2004; Patent date: Dec. 4, 2007. Inventors: Drs. Nancy CARRASCO (New York, USA), Orsolya DOHAN (New York, USA), Uygar H. TAZEBAY (Bilkent, Turkey), Irene L. WAPNIR (Stanford, USA).