Prof. Dr. Emel TİMUÇİN
Moleküler Biyoloji ve Genetik

Emel TİMUÇİN
Telefon
(262) -
E-Posta
emelt@gtu.edu.tr
Web sayfası
https://timucinlab.com/
Ofis
C2 Blok, 214
Ofis saatleri
 
Çalışma alanları
Hesaplamalı yapısal biyoloji

1. Buyukcolak-Cebeci, Y., et al., Determination of the Roles of H. pylori Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1beta, and IL-18 in Ulcer and Gastritis Pathogenesis. Biology (Basel), 2025. 14(6).
2. Koldas, S.S., O.U. Sezerman, and E. Timucin, Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis. mSystems, 2025. 10(6): p. e0019625.
3. Kurt-Sukur, E.D., et al., A Novel NUP85 Variant Expanding the Phenotypic Spectrum of NUP85-Associated Steroid-Resistant Nephrotic Syndrome. Clin Genet, 2025. 108(1): p. 75-79.
4. Oztug Durer, Z.A., et al., Insights into the solution structure of the actin-binding tail domain of metavinculin by small angle X-ray scattering and molecular dynamics simulations. Int J Biol Macromol, 2025. 319(Pt 3): p. 144376.
5. Pir, M.S. and E. Timucin, AFFIPred: AlphaFold2 structure-based Functional Impact Prediction of missense variations. Protein Sci, 2025. 34(2): p. e70030.
6. Sardag, I., et al., Computational modeling of the anti-inflammatory complexes of IL37. J Mol Graph Model, 2025. 136: p. 108952.
7. Akcelik-Deveci, S., et al., Identification of interaction partners of outer inflammatory protein A: Computational and experimental insights into how Helicobacter pylori infects host cells. PLoS One, 2024. 19(10): p. e0300557.
8. Rijo, P., et al., Editorial: Women in experimental pharmacology and drug discovery 2023. Front Pharmacol, 2024. 15: p. 1439405.
9. Sardag, I., et al., Rational design of monomeric IL37 variants guided by stability and dynamical analyses of IL37 dimers. Comput Struct Biotechnol J, 2024. 23: p. 1854-1863.
10. Altiner, P., et al., Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex. Sci Rep, 2023. 13(1): p. 18399.
11. Keskin Karakoyun, H., et al., Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer. Front Genet, 2023. 14: p. 1052383.
12. Kucuk, T., et al., Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients. J Assist Reprod Genet, 2023. 40(8): p. 1933-1941.
13. Oktem-Okullu, S., et al., Effect of the switch status of Helicobacter pylori outer inflammatory protein A on gastric diseases. AMB Express, 2023. 13(1): p. 109.
14. Shehata, M., et al., Brave new surfactant world revisited by thermoalkalophilic lipases: computational insights into the role of SDS as a substrate analog. Phys Chem Chem Phys, 2023. 25(3): p. 2234-2247.
15. Yazici, Y.Y., S. Belkaya, and E. Timucin, A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers. Comput Struct Biotechnol J, 2023. 21: p. 3522-3531.
16. Kebabci, N., A.C. Timucin, and E. Timucin, Toward Compilation of Balanced Protein Stability Data Sets: Flattening the DeltaDeltaG Curve through Systematic Enrichment. J Chem Inf Model, 2022. 62(5): p. 1345-1355.
17. Kilinc, E., et al., Modeling and dynamical analysis of the full-length structure of factor XII with zinc. J Mol Model, 2022. 28(5): p. 129.
18. Le, H.H., et al., Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells. EBioMedicine, 2021. 73: p. 103646.
19. Timucin, A.C., et al., Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS. Front Chem, 2021. 9: p. 716438.
20. Cinaroglu, S.S. and E. Timucin, Comprehensive evaluation of the MM-GBSA method on bromodomain-inhibitor sets. Brief Bioinform, 2020. 21(6): p. 2112-2125.
21. Shehata, M., et al., Understanding thermal and organic solvent stability of thermoalkalophilic lipases: insights from computational predictions and experiments. J Mol Model, 2020. 26(6): p. 122.
22. Shehata, M., et al., Lipase and Water in a Deep Eutectic Solvent: Molecular Dynamics and Experimental Studies of the Effects of Water-In-Deep Eutectic Solvents on Lipase Stability. J Phys Chem B, 2020. 124(40): p. 8801-8810.
23. Alaca, N., et al., Translation and cross-cultural adaptation of the extended version of the Nordic musculoskeletal questionnaire into Turkish. J Musculoskelet Neuronal Interact, 2019. 19(4): p. 472-481.
24. Cinaroglu, S.S. and E. Timucin, Comparative Assessment of Seven Docking Programs on a Nonredundant Metalloprotein Subset of the PDBbind Refined. J Chem Inf Model, 2019. 59(9): p. 3846-3859.
25. Cinaroglu, S.S. and E. Timucin, Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors. J Mol Model, 2019. 25(5): p. 130.
26. Cinaroglu, S.S. and E. Timucin, In silico identification of inhibitors targeting N-Terminal domain of human Replication Protein A. J Mol Graph Model, 2019. 86: p. 149-159.
27. Lucas, S., et al., The drought response displayed by a DRE-binding protein from Triticum dicoccoides. Plant Physiol Biochem, 2011. 49(3): p. 346-51.
28. Durmaz, E., S. Kuyucak, and U.O. Sezerman, Modifying the catalytic preference of tributyrin in Bacillus thermocatenulatus lipase through in-silico modeling of enzyme-substrate complex. Protein Eng Des Sel, 2013. 26(5): p. 325-33.
29. Timucin, E. and O.U. Sezerman, The conserved lid tryptophan, W211, potentiates thermostability and thermoactivity in bacterial thermoalkalophilic lipases. PLoS One, 2013. 8(12): p. e85186.
30. Tada, S., et al., Direct in vitro selection of titanium-binding epidermal growth factor. Biomaterials, 2014. 35(11): p. 3497-503.
31. Timucin, E. and O.U. Sezerman, Zinc Modulates Self-Assembly of Bacillus thermocatenulatus Lipase. Biochemistry, 2015. 54(25): p. 3901-10.
32. Erbil, S., et al., RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy. J Biol Chem, 2016. 291(32): p. 16753-65.
33. Timucin, E., et al., Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5. Proteins, 2016. 84(1): p. 129-42.
34. Yukselen, O., E. Timucin, and U. Sezerman, Predicting the impact of mutations on the specific activity of Bacillus thermocatenulatus lipase using a combined approach of docking and molecular dynamics. J Mol Recognit, 2016. 29(10): p. 466-75.
35. Timucin, E. and O.U. Sezerman, Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants. J Chem Inf Model, 2018. 58(3): p. 661-672.

Ders Kodu Ders Adı
  • Doktora: Biological Sciences and Bioengineering, Sabanci University
  • Yüksek lisans:
  • Lisans: Molecular Biology and Genetics, METU