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Dr. Öğr. Üyesi Mehmet Fatih SAĞLAM
Kimya

Mehmet Fatih SAĞLAM
Telefon
(262) 605 30 18
E-Posta
mfsaglam@gtu.edu.tr
Ofis
Kimya, 250
Çalışma alanları
Design and Synthesis of Organic Compounds; Conjugated Hydrocarbons(Dendralenes,Polyenes), Heterocyclic Compounds(Carbazoles,Indoles), Naphthazarins, BODIPY, C-C bond forming Cross-Coupling Rxns

Uluslararası hakemli dergilerde yayımlanan makaleler:

1) M. F. Saglam, T. Fallon, M. N. Paddon-Row, M. S. Sherburn “Discovery and Computational Rationalization of Diminishing Alternation in [n]Dendralenes” J. Am. Chem. Soc. 2016, 138, 1022-1032. DOI:https://doi.org/10.1021/jacs.5b11889

This article was spotlighted in the Journal of American Chemical Society by C. Herman “New Study Sheds Light On A Family Of Branched Molecules” J. Am. Chem. Soc. 2016, 138, 703.
This article was highlighted in the Chemical Engineering News by S. K. Ritter “Chemists Welcome More Dendralenes To The Family” CEN 2016, 94, 28

2) M. F. Saglam, A. R. Alborzi, A. D. Payne, A. C. Willis, M. N. Paddon-Row, M. S. Sherburn “Synthesis and Diels–Alder Reactivity of Substituted [4]Dendralenes” J. Org. Chem. 2016, 81, 1461-1475. DOI:https://doi.org/10.1021/acs.joc.5b02583

This article was chosen as the ACS Editors’ Choice open access publication for 29 January 2016.

3) M. Bingul, M. F. Saglam, H. Kandemir, M. Boga, I. F. Sengul "Synthesis of Indole-2-Carbohydrazides and 2-(Indolyl)-1,3,4-Oxadiazoles as Antioxidant and Their Acetylcholinesterase Inhibition Properties” Monatsh. Chem. 2019, 150, 1553-1560. DOI: https://doi.org/10.1007/s00706-019-02462-y

4) M. Bingul, E. Şenkuytu, M. F. Saglam, M. Boga, H. Kandemir, I. F. Sengul “Synthesis, Photophysical and Antioxidant Properties of Carbazole-Based Bis-Thiosemicarbazones” Res. Chem. Intermediat. 2019, 45, 4487-4499. DOI: https://doi.org/10.1007/s11164-019-03844-x

5) E. Şenkuytu, M. Bingul, M. F. Saglam, H. Kandemir, I. F. Sengul “Synthesis of a Novel N,N',N'-tetraacetyl-4,6-dimethoxyindole-Based Dual Chemosensor for the Recognition of Fe3+ and Cu2+ Ions” Inorganica Chim. Acta. 2019, 495, 118947. DOI: https://doi.org/10.1016/j.ica.2019.05.046

6) S. Ayari, M. F. Saglam, E. Şenkuytu, P. B. Erçin, Y. Zorlu, I. F. Sengul, B. Jamoussi, D. Atilla “3-Methylindole Substituted Zinc Phthalocyanines for Photodynamic Cancer Therapy” J. Porphyr. Phthalocya. 2019, 23, 1371-1379 DOI: https://doi.org/10.1142/S1088424619501426

7) M. F. Saglam, M. Bingul, E. Şenkuytu, M. Boga, Y. Zorlu, H. Kandemir, I. F. Sengul “Synthesis, Characterization, UV-Vis Absorption and Cholinesterase Inhibition Properties of Bis-Indolyl Imine Ligand Systems” J. Mol. Struct. 2020, 1215, 128308. DOI: https://doi.org/10.1016/j.molstruc.2020.128308

8) H. Kandemir, M. F. Saglam, I. F. Sengul “Synthesis of Methylene Bridged Bis-pyrrolo[3,2-c] Carbazoles via an Unusual Vilsmeier-Haack Product of N-ethylcarbazole” Polycycl. Aromat. Comp. 2020, 40, 516-523. DOI: https://doi.org/10.1080/10406638.2018.1458739

9) S. Ayari, K. Hirabayashi, T. Shimizu, B. Jamoussi, M. F. Saglam, D. Atilla, Ken-ichi Sugiura “Crystal Structure of 3-(3-Methyl-1H-indole-1-yl)phthalonitrile” X-Ray Structure Analysis Online.160;2020, 36, 11-13. DOI: https://doi.org/10.2116/xraystruct.36.11

10) K. Harmandar, E. N. Kaya, M. F. Saglam, I. F. Sengul, D. Atilla “Bis-Indole Substituted Phthalocyanines: Photophysical and Photochemical Properties” J. Porphyr. Phthalocya. 2021, 25, 66-74. DOI: https://doi.org/10.1142/S1088424620500522

11) K. Harmandar, M. F. Saglam, I. F. Sengul, G. Ekineker, P. Balcik-Ercin, M. Göksel, D. Atilla “Novel Triazole Containing Zinc(II)Phthalocyanine Schiff Bases: Determination of Photophysical and Photochemical Properties for Photodynamic Cancer Therapy”, Inorganica Chim. Acta. 2021, 519, 120286. DOI: https://doi.org/10.1016/j.ica.2021.120286

12) M. F. Saglam*, A. Gündogdu, M. Hora, H. Kandemir, I. F. Sengul “Synthesis of Pyrrolo[3,2-c]carbazole-2-carbohydrazide and Pyrrolo[3,2-c]carbazol-2-yl-1,3,4-oxadiazole and Their in vitro Antibacterial Evaluation”, Synth. Commun. 2021, 51, 3164-3174. DOI: https://doi.org/10.1080/00397911.2021.1966040

13) K. Harmandar, E. N. Kaya, M. F. Saglam*, I. F. Sengul, D. Atilla “Synthesis and Photo-physicochemical Properties of Phthalocyanines Substituted with Sterically Hindered Phenol” Monatsh. Chem. 2021, 152, 1561–1569. DOI: https://doi.org/10.1007/s00706-021-02864-x

14) M. Yıldız, M. Bingul, Y. Zorlu, M. F. Saglam, M. Boga, M. Temel, M. S. Koca, H. Kandemir, I. F. Sengul "Dimethoxyindoles Based Thiosemicarbazones as Multi-Target Agents; Synthesis, Crystal Interactions, Biological Activity and Molecular Modeling" Bioorg. Chem. 2022, 120, 105647. DOI: https://doi.org/10.1016/j.bioorg.2022.105647

15) M. F. Saglam* “Synthesis and structural elucidation of 2,3-dimethylnaphthazarin ester derivatives” Arkivoc. 2022, part ix, 199-211. DOI: https://doi.org/10.24820/ark.5550190.p011.961

16) H. Kandemir, S. İzgi, I. Cınar, F. Cebeci, E. Dirican, M. F. Saglam, I. F. Sengul “Methoxy-Activated Indole-7-Carbohydrazides; Synthesis, Antioxidant and Anticancer Properties" J. Heterocycl. Chem. 2023;60:74–85. DOI: https://doi.org/10.1002/jhet.4562

17) B. Topaloğlu Aksoy, H. H. Kazan, I. Erol, H. Kandemir, M. F. Saglam, I. F. Sengul, B. Çoşut “Investigation of spectroscopic properties of mono and Di-styrylindole-containing BODIPYs” Inorganica Chim. Acta. 2023, 544, 121230 DOI: https://doi.org/10.1016/j.ica.2022.121230

18) M.Tepe, Ş. Abadan, M. F. Saglam, V.Süzerer, P. Balçık Erçin, D. Atilla, E. Erciyas Baykal, M. G. Şeker, T. Yağcı, Y. Özden Çiftçi “In Vitro Mass Production, Chemical Modification, and Cytotoxicity of Shikonin Derivatives on Breast Cancer Cells” Ind. Crops. Prod. 2023, 192, 116087. DOI: https://doi.org/10.1016/j.indcrop.2022.116087

19) Ş. Abadan, M. F. Saglam*, M. S. Koca, M. Bingul, H. Sahin, Y. Zorlu, I. F. Sengul ”Synthesis and Molecular Modeling Studies of Naphthazarin Derivatives as Novel Selective Inhibitors of α-Glucosidase and α-Amylase” J. Mol. Struct. 2023, 1278, 134954. DOI: https://doi.org/10.1016/j.molstruc.2023.134954

20) E. Ozcan, M. F. Saglam, H. H. Kazan, I. Erol, I. F. Sengul, B. Cosut, “Indolyl Imine Substituted BODIPY Systems; Synthesis, Photophysical and Biological Properties”, Tetrahedron. 2023, 137, 133367.
DOI: https://doi.org/10.1016/j.tet.2023.133367

21) B. Topaloğlu Aksoy, A. Senocak, I. Erol, M. F. Saglam, H. Kandemir, I. F. Sengul, B. Çoşut “Meso Carbazole Linked Bis-BODIPYs: Design, Synthesis, Structures and Properties” Tetrahedron. 2023, 147, 133666. DOI: https://doi.org/10.1016/j.tet.2023.133666

Ulusal hakemli dergilerde yayımlanan makaleler:

M. F. Saglam* “Synthesis, Characterization and Thermal Analysis of Novel Methylene Bridged Bis-carbazole Based Bis-benzimidazoles” Hittite J. Sci. Eng. 2022, 9 (4), 281-286. DOI: https://doi.org/10.17350/HJSE19030000281

Uluslararası kitaplarda yazılan kitap bölümü:
N. J. Green,M. F. Saglam, M. S. Sherburn “Synthesis of Dendralenes” Book Chapter in Cross Conjugation: Modern Dendralene, Radialene and Fulvene Chemistry, 1st Edn., WILEY-VCH Verlag GmbH Co. KGaA., 2016. ISBN: 978-3-527-33437-7.

Uluslararası bilimsel toplantılarda sunulan ve bildiri kitaplarında (proceedings) basılan bildiriler:

1) M. F. Saglam “Rapid Generation of Fused Ring Systems” 2nd International Conference (Hybrid) Recent Trends in Natural Sciences (RTNS-2023), University of Education, Jauharabad Campus, Pakistan, 03-04 May 2023. (Invited Lecture - Oral Presentation)

2) M. F. Saglam “Design of New Important Organic Frameworks” 1st International Conference (Hybrid) Recent Trends in Natural Sciences (RTNS-2022), University of Education, Jauharabad Campus, Pakistan, 01-02 June 2022. (Invited Lecture - Oral Presentation)

3) M. F. Saglam, T. Fallon, M. S. Sherburn “The Last Branch of the Dendralene Story” 35th Annual One-Day Symposium, The Australian National University, Canberra, Australia, 3 December 2014. (Invited Lecture - Oral Presentation)

4) M. F. Saglam “Synthesis of Organic Frameworks using Suzuki-Miyaura Cross-Coupling Reaction” 4th International Congress on Applied Sciences, Engineering and Mathematic Congress, Trakya, Turkey, 20-23 October 2022. (Oral Presentation)

5) M. F. Saglam “Design, Synthesis and Spectroscopic Investigation of Imine Linked Indole Bearing New BODIPY Compounds” 4th Organic Chemistry Congress, Antalya, Turkey, 04-07 October 2018. (Oral Presentation)

6) M. F. Saglam “Synthesis of Methylene Bridged Bis-Pyrrolo[3,2,c]Carbazoles” 7th International Drug Chemistry Conference, Antalya, Turkey, 14-17 March 2019. (Oral Presentation)

7)M. F. Saglam, E. Özcan, H. H. Kazan, H. Kandemir, B. Cosut, I. F. Sengul “Synthesis, Spectroscopic and Biological Studies of Indolyl-Imine Containing New BODIPY Compounds” 7th International Drug Chemistry Conference, Antalya, Turkey, 14-17 March 2019. (Poster Presentation)

8) B. Topaloğlu, M. F. Saglam, H. H. Kazan, H. Kandemir, B. Cosut, I. F. Sengul “Indole Containing New BODIPY Compounds; Investigation of Their Spectroscopic and Biological Properties” 7th International Drug Chemistry Conference, Antalya, Turkey, 14-17 March 2019. (Poster Presentation)

9) B. Topaloğlu, M. F. Saglam, H. Kandemir, B. Cosut, I. F. Sengul “Methoxy Activated Indole-Bodipy Compounds; Investigation of Synthesis and Spectroscopic Properties” 4th Organic Chemistry Congress, Antalya, Turkey, 04-07 October 2018. (Poster Presentation)

10) M. F. Saglam, T. Fallon, M. S. Sherburn “Higher Dendralenes” Royal Australian Chemical Institute, 34th Annual One-Day Symposium, The Australian National University, Canberra, Australia, 4 December 2013. (Poster Presentation)

11) N. J. Green, M. F. Saglam, M. S. Sherburn “Taming [4]Dendralenes” Royal Australian Chemical Institute, 34th Annual One-Day Symposium, The Australian National University, Canberra, Australia, 4 December 2013. (Poster Presentation)

12) M. F. Saglam, T. Fallon, M. S. Sherburn “The Higher Dendralenes Revealed! Syntheses, Chemical and Physical Properties” 23rd International Symposium: Synthesis in Organic Chemistry, University of Oxford, Oxford, England, United Kingdom, 22-25 July 2013. (Poster Presentation)

13) M. F. Saglam, T. Fallon, M. S. Sherburn “Higher Dendralenes” 19th International Conference on Organic Synthesis, Melbourne, Australia, 1-6 July 2012. (Poster Presentation)

14) M. F. Saglam, A. R. Alborzi, A. C. Willis, M. N. Paddon-Row, M. S. Sherburn “Synthesis and Diels–Alder Reactions of Substituted [4]Dendralenes” Royal Australian Chemical Institute, 32nd Annual One-Day Symposium, The University of New South Wales, Sydney, Australia, 30 November 2011. (Poster Presentation)

15) M. F. Saglam, A. R. Alborzi, A. C. Willis, M. N. Paddon-Row, M. S. Sherburn “Synthesis and Diels–Alder Reactions of Substituted [4]Dendralenes” 22nd Southern Highlands Conference on Heterocyclic Chemistry, Moss Vale, Australia, 28-30 August 2011. (Poster Presentation)

Ulusal bilimsel toplantılarda sunulan ve bildiri kitaplarında basılan bildiriler:

1) K. Harmandar, M. F. Saglam, İ. F. Şengül, D. Atilla “Fotodinamik Terapi Uygulamaları İçin Yeni Triazol Sübstitüe Zn(II) Ftalosiyaninler” 31. Ulusal Kimya Kongresi, İstanbul, Türkiye, 10-13 Eylül 2019. (Poster Sunumu)

2) K. Harmandar, E. N. Kaya,M. F. Saglam, I. F. Sengul, D. Atilla “Fotodinamik Terapi Uygulamaları İçin Bis-indol Sübstitüe Zn(II) Ftalosiyaninler” 32. Ulusal Kimya Kongresi, Online, Türkiye, 17-19 Eylül 2020. (Sözlü Sunum)

3) İ. F. Şengül, H. Kandemir, M. S. Koca, M. Temel, M. Boğa, M. F. Saglam, Y. Zorlu, M. Yıldız “İndol TemelliTiyosemikarbazon Bileşiklerinin Sentezi ve Karakterizasyonu” 33. Ulusal Kimya Kongresi,Online, Türkiye, 7-9 Ekim 2021.(Sözlü Sunum)

Yönetilen Tezler:

Şebnem Abadan, Yüksek Lisans Tezi
Tez Başlığı: “Naftazarin ve Naftazarin Çekirdek Yapısına Sahip Bazı Doğal Ürünlerin Ester Türevlerinin Sentezi
Gebze Teknik Üniversitesi, Fen Bilimleri Enstitüsü, Kimya, 2023.

  • Doktora: The Australian National University - 2016
    Research School of Chemistry, AUSTRALIA
  • Yüksek lisans: The Australian National University - 2010
    Research School of Chemistry, AUSTRALIA
  • Lisans: Kocaeli University - 2006
    Department of Chemistry, TURKEY

Yürütücü Olarak Çalışılan Projeler:

1) TÜBİTAK 1002 – Hızlı Destek Programı Projesi - 120Z069 “Pirol Karbazol Temelli Yeni 1,3,4-Oksadiazol Türevlerinin Sentezi ve Anti-bakteriyel Aktivitelerinin İncelenmesi” M. F. Saglam (Yürütücü), (Proje tamamlandı).
2) GTÜ BAP Projesi - 2019-A-105-37 “Bis-indolil Ligand Sistemlerinin Sentezi ve Karakterizasyonu” M. F. Saglam (Yürütücü), (Proje tamamlandı).
3) GTÜ BAP Projesi - 2018-A105-26 “İmin Bağlı İndol İçeren Yeni BODİPY Bileşiklerinin Sentezi ve Spektroskopik Özelliklerinin İncelenmesi” M. F. Saglam (Yürütücü), (Proje tamamlandı).

Araştırmacı Olarak Çalışılan Projeler:

1) TÜBİTAK 1001 - Bilimsel ve Teknolojik Araştırma Projesi -119Z092 “Biyoteknolojik Olarak Üretilen Yerel Bitki Kaynaklı Şikonin ve Kimyasal Türevlerinin Anti-Tümor Etkinliğinin Araştırılması” M. F. Saglam (Araştırmacı), (Proje tamamlandı).
2) TÜBİTAK 1002 – Hızlı Destek Programı Projesi - 222Z234 “1,3,4-Oksadiazol Köprüsü İçeren İkili İndol Sistemlerinin Sentezi ve Antidiyabetik Özelliklerinin İncelenmesi” M. F. Saglam (Araştırmacı), (01.05.2023 - Proje devam ediyor).
3) NKÜ BAP Projesi - NKUBAP.01.GA.22.358 “Meso-substitue Yeni Karbazol Bodipy Bileşiklerinin Sentezi ve Spektroskopik Özelliklerinin İncelenmesi” M. F. Saglam (Araştırmacı), (Proje tamamlandı).
4) GTÜ BAP Projesi - 2018-A-105-35 “Metoksi İle Aktifleştirilmiş İndol-Bodipy Maddeleri; Sentezi ve Spektroskopik Özelliklerinin İncelenmesi” M. F. Saglam (Araştırmacı), (Proje tamamlandı).
5) GTÜ BAP Projesi - 2021-A-101-04 “İndolil İmin Bileşiklerinin Sentezi ve Karakterizasyonu” M. F. Saglam (Araştırmacı), (Proje tamamlandı).
6) GTÜ BAP Projesi - 2022-A-105-44 “Bis-İndole Temelli Tiyosemikarbazon Bileşiklerinin Sentezi ve Karakterizasyonu” M. F. Saglam (Araştırmacı), (18.07.2022 - Proje devam ediyor).
7) GTÜ BAP Projesi - 2023-A-105-13 “Yeni İndol Temelli 1,3,4-Oksadiazol Bileşiklerinin Sentezi ve Karakterizasyonu” M. F. Saglam (Araştırmacı), (2023 - Proje devam ediyor).

Bilimsel Toplantılardaki Görevler:

The Third Anatolian Conference on Organic Chemistry (ACOC3), Antalya, TÜRKİYE, 13-16 Mart 2023- Organizasyon Komitesi.

Ödüller:

1) Yurtdışı Doktora Eğitimi Bursu, The Australian National University, ANU PhD HDR Merit Scholarships, 2010.
2) Türkiye Cumhuriyeti Milli Eğitim Bakanlığı Yurtdışı Yabancı Dil ve Yüksek Lisans Eğitimi Bursu, 2007.
3) Kimya Bölüm Birinciliği, Kocaeli Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 2006.
4) Onur Derecesi, Kocaeli Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 2006.
5) Onur Derecesi, Kocaeli Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 2005.
6) Onur Derecesi, Kocaeli Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümü, 2004.
7) Bilimsel Konferans Seyahat Bursu, The Australian National University, Vice-Chancellor’s Travel Grant for Higher Degree Research, 2013.
8) Bilimsel Konferansa Katılım Bursu, The Australian National University, Research School of Chemistry, 2013.
9) Bilimsel Konferansa Katılım Bursu, Royal Australian Chemical Institute, 2011.
10) The article “Synthesis and Diels–Alder Reactivity of Substituted [4]Dendralenes” was selected by the journals' Editors to be featured in ACS Editors' Choice and has been sponsored for immediate open access by American Chemical Society.