Webinar #12: Model Sistemlerde ve Organizmalarda Rejeneratif Tıp Araştırmaları

 

This webinar was not published on our Youtube channel upon the request of the speaker.

 

Özet:

Regeneration; it is the name given to the process of regeneration and functioning of lost or damaged cells, tissues and organs. Molecular pathways involved in this process regulate the steps of immune system modulation, increase in stem cell activity and formation of different cells for functional restoration. Why some living things have a high regenerative capacity while the vast majority do not have this capacity or cannot use their existing regenerative potential is an exciting topic of scientific research. Axolotls, which are among the water salamanders, can regenerate their arms, tail, internal organs including the heart, and the central nervous system including the brain and spinal cord in their larval and adult life cycles. The high regenerative capacity of axolotls made them important model organisms in regeneration and stem cell studies. Although these creatures do not naturally undergo metamorphosis, they can be induced by the administration of thyroid hormone, and as an interesting result, the regeneration capacity of metamorphic creatures decreases. The main body of our work in our lab is to understand the cellular and molecular bases of regeneration and to test the lessons learned in the mammalian system and to make their translational applications. In this context, in addition to two and three dimensional cell culture models, experimental animals such as axolotl, spalax, mouse and rat are also used in our studies. In addition to basic molecular genetic techniques to explain the questions we seek, we are extensively used in our studies of CRISPR-mediated genome engineering, next-generation RNA sequencing, proteomics and metagenomics applications and bioinformatics analysis.

Keywords: Axolotl, Regeneration, Regenerative Medicine, OMICS, Systems Biology

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