Laboratory Name |
Cancer Signal Transduction and Apoptosis Lab (CASTAL) |
Laboratory Responsible |
Assist. Prof. Asuman D. Zergeroğlu |
Department |
Molecular Biology and Genetics |
Telephone |
+90 262 605 2513 |
Address |
Gebze Institute of Technology |
General Information |
Signalling mechanisms are central to the normal growth and development of all cells. Cells have to continuously respond to extracellular signals that prompt specific cellular responses inducing cell proliferation, inhibiting cell growth and triggering programmed cell death. Dysregulation of these systems leads to a variety of human diseases, including cancer. A major interest of our laboratory is studying cancer-related signal transduction and its effects on cellular growth, survival and apoptosis. In this sense, our aim is to identify molecularly targeted therapeutic approaches to modulate cancer cell growth, survival and apoptosis. In our lab effects of some natural products (e.g.: polyphenols), tyrosine kinase inhibitors, and design potent and selective drug candidates have been investigated in normal and cancer cells. |
Laboratory Staff |
PhD Students |
Applications |
1. Determine the dose and time dependent effect of anti-carcinogenic agents on cell proliferation by using colorimetric, fluorometric and luminometric measurements. |
Equipment |
1. Laminair flow |