Doç. Dr. F. İnci ÖZDEMİR
Moleküler Biyoloji ve Genetik

F. İnci ÖZDEMİR
Telefon
(262) 605 25 16 - 25 35
E-Posta
i.ozdemirgtu.edu.tr
Ofis
C2 Blok, 0 262 605 2516
Çalışma alanları
PROTEAZLAR; Termofilik bakterilerde ATP-bağımlı(Proteazom, HslVU, Lon, FtsH proteazlar) ve geleneksel proteazlar(Asparaginaz, Lipaz, Proteaz). Siderofor üretimi.

Journal Article

1.Özdemir F.İ., Tülek A., Karaaslan B., Yildirim D., Evaluation of multi-walled carbon nanotubes bearing aldehyde groups of different lengths for the immobilization of Geobacillus kaustophilus l-asparaginase, Molecular Catalysis. 2024, 555,113903, https://doi.org/10.1016/j.mcat.2024.113903.

2.Özdemir F.İ., Tülek A., Karaaslan B., Yildirim D (2023).Covalent Immobilization of Recombinant
L-Asparaginase from Geobacillus kaustophilus on ReliZymesupports for Mitigation of Acrylamide. Biocatalysis and Biotransformation 2023 15 Sep, https://doi.org/10.1080/10242422.2023.2257351

3.Özdemir F.İ., Korkmaz T. Çevresel Kosulların Termofilik Geobacillus kaustophilus’da Biyofilm Olusumu Üzerinde Etkisi. Igdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi. 2023, 13(3), 1562-1572. http://doi:10.21597/jist.1295306.

4. Özdemir F.İ., Aydın B., Tülek A. Investigation of the Siderophore Production and Associated Heavy Metal Accumulation Potential of Brevibacillus laterosporus 301/IK3-2. Hacettepe Journal of Biology and Chemistry. 2023, 51(3), 317-325, https://doi:10.15671/hjbc.

5. Özdemir F:İ., Karaaslan B.,Tülek A.,Yucebilgic G.,Yildirim D., Immobilization of recombinant L-asparaginase from Geobacillus kaustophilus on magnetic MWCNT-nickel composites, Process Biochemistry, 2023 Apr, 127:10-20, doi:10.1016/j.procbio.2023.01.021.

6.Özdemir F.İ., Didem O.M., Atasavum Z.T., Tülek A.Biochemical characterization and detection of antitumor activity of l-asparaginase from thermophilic Geobacillus kaustophilus DSM 7263T. Protein
Expression and Purification. 2022 Jul 19; 199:106146. doi:10.1016/j.pep.2022.106146.

7.Özdemir F.İ., Tülek A., Erdoğan D., Identification and Heterologous Production of a Lipase
from Geobacillus kaustophilus DSM 7263T and Tailoring Its N-Terminal by a His-Tag Epitope, The Protein Journal, 2021 Apr 15. DOI: 10.1134/S0003683820060186.

8. Yılmaz H., Ergenekon P., Özdemir İ., Özkan M.., Affinity tag effect on the salt rejection potential
of Halomonas elongata aquaporin incorporated in thin film nanocomposite membrane, Protein
Expression and Purification, 2020, 173 September,105664. DOI: 10.1016/j.pep.2020.105664.

9. Tülek A., Özdemir F.İ, Ramadhan S.S., Cloning, expression and characterization of membrane bound FtsH protease of Geobacillus kaustophilus., Applied Biochemistry and Microbiology Accepted March, 2020.DOI: 10.1007/s10930-021-09987-4.

10. Kocabıyık S., Ozdemir İ., Zwickl P., Ozdoğan S., Molecular cloning and co-expression of Thermoplasma volcanium proteasome subunit genes., Protein Expression and Purification , 2010,160;223-230. DOI: 10.1016/j.pep.2010.05.004.

11. Kocabıyık S., Ozdemir İ., Purification and characterization of an intracellular chymotrypsin-like serine protease from Thermoplasma volcanium, Bioscience, Biotechnology, and Biochemistry, 2006 Jan; 70(1):126-34.DOI: 10.1271/bbb.70.126.

Conference Proceedings

1.Ozdemir, I., Orhan, M.D. Cloning, purification and identification of antitumor activity of themophilic Geobacillus kaustophilus L-asparaginase, Eurosian Congres on Molecular Biotechnology,
2019, Abstract Book, p.4, Trabzon, Turkey, September 19-20.

2. Ozdemir, I., Ramadhan ,S.S., Tulek, A. Biochemichal  of N-terminally truncated FtsH protease of Geobacillus kaustophilus, FEMS 2017 ;Congress of European Microbiologist abstract number:3057, July 9-13, Valencia, Spain.

3. Ozdemir, F.I., Asal, Z., Camcı, H. Purification and characterisation of recombinant Geobacillus kaustophilus protein Lon from E. coli. New Biotechnology, Abstract of the 15th European Congres on Biotechnology,p.85 ,İstanbul, Turkey, Semptember 23-26, 2012.

4. Turkan, A., Ozdemir, I., Erdogan, D., Kalay, S. Cloning, exspression and characterisation of a lipase from thermophilic bacterium Geobacillus kaustophilus and its immobilization studies. European Biotechnology Congress 2011, Abstract Book, p.83, Istanbul, Turkey. September 28- October 1, 2011.

5. Ozdemir, I., Avican K., Altin G. Cloning and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from thermophilic Geobacillus kaustophilus. European Biotechnology Congress 2011, Abstract Book, p.84, Istanbul, Turkey. September 28-October 1, 2011.

6. Kocabiyik, S. and Ozdemir, I., 20S Proteasome Complex from Thermoplasma volcanium. 27th Meeting of the Federation of European Biochemical Societies, Abstract Book, p.199, Lisbon, Portugal. June 30-July 5, 2001.

7. Ozdemir, I. and Kocabiyik, S., Purification and Characterization of a Thermostable Serine Protease from Thermoplasma volcanium. 27th Meeting of the Federation of European Biochemical Societies. Abstract Book, p.193, Lisbon, Portugal, June 30-July 5, 2001.

8. Kocabiyik, S. and Ozdemir, I., Differential Amplification of 16S rDNA Sequences of Archaea and Bacteria from Solfataric Hot-Springs in Turkey. 18th IUBMB Congress, Abstract Book, p.550, Birmingham, UK, July16-20, 2000.

National Proceedings

1. Korkmaz, T. and Özdemir, I., Effects of Environmental Stress Conditions on Biofilm Formation by Thermophilic Geobacillus kaustophilus (Presentation). 21th National Biology Congress, Abstract Book, p.266, İzmir, Turkey, September 3-7, 2012.

2. Ozdemir, I. and Kocabiyik, S. Isolation and characterization of 20S proteasome from Thermoplasma volcanium. 17th National Biochemistry Congress,Abstract Book, p.136, Ankara, Turkey, June 24-27, 2002.

3. Seyit, G., Ozdemir, I. and Kocabiyik, S. Isolation, purification and cloning of alkaline serine proteases from thermophilic archaeon, Thermoplasma volcanium. 17th National Biochemistry Congress, Abstract Book, p.27, Ankara, Turkey, June 24-27, 2002.

4. Kocabiyik, S. and Ozdemir, I., Isolation of thermophilic archaea and bacteria from natural hot-springs in Turkey and cloning of an archaea originated serine protease gene in E. coli. (Presentation) Turkey Agricultural Research Project Symposium, Abstract Book, p.16-17, TUBITAK, Ankara, Turkey,October 26-27, 2000.

Citations

  1. Wentao Yao, Kaiquan Liu1,2, Hongling Liu, Yi Jiang, Ruiming Wang, Wei Wang and Tengfei Wang, A Valuable Product of Microbial Cell Factories: Microbial Lipase Front. Microbiol., 20 September 2021 DOI:10.3389/fmicb.2021.743377
  2. Xiao, J.-J., Zhang, R.-X., Khan, A., ul Haq, S., Gai, W.-X., Gong, Z.-H. CaFtsH06, A Novel Filamentous Thermosensitive Protease Gene, Is Involved in Heat, Salt, and Drought Stress Tolerance of Pepper (Capsicum annuum L.). Int. J. Mol. Sci. 2021, 22, 6953. DOI. 10.3390/ijms22136953
  3. Angelo Beratto-Ramos, Jorge Dagnino-Leone, José Martínez-Oyanedel, Mario
    Aranda & Rodrigo Bórquez (2021) Fabrication and Filtration Performance of
    Aquaporin Biomimetic Membranes for Water Treatment, Separation &
    Purification Reviews, DOI: 10.1080/15422119.2021.1948865
  4. Carlos Eduardo Duffeck, Cíntia Lionela Ambrósio de Menezes, Maurício Boscolo, Roberto da Silva, Eleni Gomes, Ronivaldo Rodrigues da Silva. (2020)
    Citrobacter diversus-derived keratinases and their potential application as detergent-compatible cloth-cleaning agents. Brazilian Journal of Microbiology 51:3, pages 969-977.
  5. Waldir Eduardo Simioni Pereira, Ronivaldo Rodrigues da Silva, Gabriela Salvador de Amo, Roberto Ruller, Luciano Takeshi Kishi, Maurício Boscolo, Eleni Gomes, Roberto da Silva.
    (2020) A Collagenolytic Aspartic Protease from Thermomucor indicae-seudaticae Expressed in Escherichia coli and Pichia pastoris. Applied Biochemistry and Biotechnology 191:3, pages 1258-1270.
  6. Ronivaldo Rodrigues da Silva, Carlos Eduardo Duffeck, Maurício Boscolo, Roberto da Silva, Eleni Gomes. (2019) Milk clotting and storage-tolerant peptidase from Aureobasidium leucospermi LB86. Process Biochemistry 85, pages 206-212.
  7. Ja’afaru, M.I. , Chimbekujwo, K.I. , Ajunwa, O.M. Purification, characterization and de-staining potentials of a thermotolerant protease produced by fusarium oxysporum (2020) Periodica Polytechnica Chemical Engineering
  8. Vasudeo Zambare, Smita Nilegaonkar, Pradnya Kanekar. (2011) A novel extracellular protease from Pseudomonas aeruginosa MCM B-327: enzyme production and its partial characterization. New Biotechnology 28:2, pages 173-181.
  9. Karina Antúnez, Matilde Anido,Daniela Arredondo, Jay D. Evans, Pablo Zunino. (2011) Paenibacillus larvae enolase as a virulence factor in honeybee larvae infection. Veterinary Microbiology 147:1-2, pages 83-89.
  10. Semra Kocabıyık, Burçak Demirok. (2009) Cloning and overexpression of a thermostable signal peptide peptidase (SppA) from Thermoplasma volcanium GSS1 in E. coli. Biotechnology Journal 4:7, pages 1055-1065.
  11. Tunçer H. Özdamar. (2009) Biotechnology in Turkey: An overview. Biotechnology Journal 4:7, pages 981-991.
  12. L. Coelho, Andréa F. S.Santos, T. Napoleão, M. Correia, P. Paiva  Protein Purification by Affinity Chromatography 2012 Chemistry DOI:10.5772/29947Corpus ID: 97502290
  13. Navneet Batra and Meenu Walia, Production and characterization of alkaline protease from bacteria strains isolated from cotton field African Journal of Microbiology Research
    Vol. 8(7), pp. 702-709, 12 February, 2014  DOI: 10.5897/AJMR2013.6526
  14. Luana C. B. B. Coelho, Andréa F. S. Santos, Thiago H. Napoleão, Maria T. S. Correia and Patrícia M. G.P. Ch. 3: Protein purification by affinity chromatography January
    2012 ;Protein Purification ;Edited by Rizwan Ahmad 2012 Protein Purification Book Affinity Chapter Luana

Didem Müge Orhan. Termofilik Geobacillus kaustophilus L-Asparajinazın Antitümör Etkisinin Belirlenmesi; M.Sc. Thesis.; Gebze Institute of Technology 2016 (Ongoing).

Salim Ramadhan. Cloning and Expression of Membrane Bound FtsH protease of Geobacillus kaustophilus in Escherichia coli; M.Sc. Thesis. Gebze Institute of Technology 2016 (Graduated).

Bahadır Aydın. Production of siderophore from Geobacillus kaustophilus under the Cd stress. M.Sc. Thesis. Gebze Institute of Technology 2014 (Graduated).

Enis Güney. Characterization of siderophore production from Bacillus cereus. M.Sc. Thesis. Gebze Institute of Technology 2014 (Graduated).

Ahmet Tülek. Cloning and expression of Geobacillus kaustophilus ftsH gene. M.Sc. Thesis. Gebze Institute of Technology 2014 (Graduated).

Tuba Korkmaz. Effects of environmental stress conditions on biofilm formation by thermophilic Geobacillus kaustophilus. M.Sc. Thesis. Gebze Institute of Technology 2012 (Graduated).

Davut Erdoğan. Cloning, expression and characterization of a lipase from thermophilic bacterium Geobacillus kaustophilus. M.Sc. Thesis. Gebze Institute of Technology 2012 (Graduated).

Hatice Zişan Asal. Purification and characterization of recombinant Geobacillus kaustophilus protein Lon from E. coli.M.Sc. Thesis. Gebze Institute of Technology 2011(Graduated).

Haluk Camcı. Cloning and expression of lon geneof Geobacillus kaustophilus. M.Sc. Thesis. Gebze Institute of Technology 2009 (Graduated).

Gonca Altın. Purification and characterization of recombinant Geobacillus kaustophilus protein HslV and HslU from E. coli. M.Sc. Thesis. Gebze Institute of Technology 2009 (Graduated).

Kemal Avican. Cloning and expression of hslV and hslU genes of Geobacillus kaustophilus. Gebze Institute of Technology 2009 (Graduated).

  • Doktora: Orta Doğu Teknik Üniversitesi Fen-Edebiyat Fakültesi Biyoloji
  • Yüksek lisans: Illinois Institute of Technology Master of Science Biology
  • Lisans: Ege Üniversitesi Fen Fakültesi Biyoloji
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