Prof. Dr. Ferruh ÖZCAN
Molecular Biology and Genetics

Ferruh ÖZCAN
Phone
+90 (262) 605 25 08 - 25 49
Email
ferruh.ozcangtu.edu.tr
Office
Block C2, 211
Areas of interest
Neuronal etiology of obesity. Protein homeostasis and secretion in hypothalamic neurons. Unfolded Protein Response, ER stress and autophagy in CNS.

N. Rousta, M. Aslan, M. Y. Akbaş, F. Özcan, T. Sar & M. J. J. Taherzadeh, Effects of fungal based bioactive compounds on human health: Review paper Critical Reviews in Food Science And Nutrition (2023) DOI 10.1080/10408398.2023.2178379

M. S. Türküner & F. Özcan. Monosodium glutamate restricts the adipogenic potential of 3T3-L1 preadipocytes through mitotic clonal expansion CELL BIOLOGY INTERNATIONAL (2020) Cilt : 44 Sayı : 3 Sayfa : 744-754

Safa Aydın, Mehmet Emir Yalvaç, Ferruh Özcan, Fikrettin Şahin, Pluronic Pf68 İncreases Transfection Efficiency in Electroporation of Mesenchymal Stem Cells. Turkish Journal of Biology, 40(4):747-754, 2016

Gamze Küser-Abalı, Ferruh Özcan, Asli Ugurlu, Avni Uysal, Stefan H. Fuss and Kuyas Bugra-Bilge. SIK2 Is Involved in the Negative Modulation of Insulin-Dependent Müller Cell Survival and Implicated in Hyperglycemia-Induced Cell Death, IOVS. (54) 3526-37, 2013

Eswarkumar, V., Özcan, F., Lew, E., Bae, J., Yan, Y., Schlessinger, J. Attenuation of Signaling Pathways Stimulated by Pathologically Activated FGF-receptor 2 Mutants Prevents Craniosynostosis, Proc Natl Acad Sci. U S A., 103 (49) 18603- 08, 2006

Ferruh Özcan, Peter Klein, Mark Lemmon, Irit Lax, Joseph Schlessinger. On the Nature of the Low and High-Affinity EGF-receptors on Living Cells. Proc Natl Acad Sci. U S A. 103(15):5735-40, 2006

Çınaroğlu, A., Y. Özmen, A. Özdemir, F. Özcan, C. Ergörül, P. Çayırlıoğlu, D. Hicks and K. Buğra.. Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina. J. Neurosci Res. 79(3): 329-339, 2005

Kedar, G. C., Özcan, F., Guzman, E. C., Smith, D. W., Newman, V. G., Zyskind, J. W.. Role of DNA methylation at GATC sites in the dnaA promoter, dnaA2. J.Mol. Mic. Biotech. 2(3): 301-310. 2000

Diğer Yayınlar. Hakemli konferans/sempozyumların bildiri kitaplarında yer alan yayınlar

A. Uysal, F. Özcan, Y. Özmen, G. Küser, K. Buğra-Bilge. The Identification of Salt-Inducible Kinase 2 (SIK2) Orthologue in Rat Retina, Invest Ophthalmol Vis Sci, 46: E-Abstract 3151. 2005.

Bugra-Bilge K, Cinaroglu A, Ozmen Y, Hicks D, Özcan, F. FGF9 expression postnatal rat retina. Invest Ophthalmol Vis Sci, 45 Abstract. 2004   </span>

Safa Aydın, Mehmet Emir Yalvaç, Aysu Yılmaz, Fikrettin Şahin, Ferruh Özcan, Albert Rizvano. Improved nonviral gene delivery into mesenchymal stem cells by using F68 pluronic block copolymer. Annual Congress on Stem Cell Research. 2011

Safa Aydın, Mehmet Emir Yalvac, Aysu Yilmaz1, Ferruh Ozcan and Fikrettin Şahin. Effect of F68 Pluronic Block Copolymer on Electroporation of HeLa Cells Abstracts of the 4th International Congress of Molecular Medicine. 2011

Samlı, F. Ozcan, K. Buğra, L. Kurnaz, "Modeling the Function of SMP Protein in the Fibroblast Growth Factor (FGF) Signaling Pathway" BIOMUT 2003 (National Biomedical Engineering Conference), Boğaziçi University, İstanbul, TÜRKİYE May, 29-30 2003.

H. Furkan Alkan, F. Seyma Özen., Ferruh Özcan. A potential novel role of SIK2 in mitotic clonal expansion of 3T3-L1 preadipocytes in 2nd International Congress of the Molecular Biology Association of Turkey 2013. Istanbul Technical University, Istanbul.

1. İnanç Burcu. (Master), Development of Optic Biosensors to Detect Certain Mycoplasma Species GTU, Institute for Graduate Studies in Natural and Applied Sciences 2008.
2. Hebip Hale. (Y. Lisans), SIK2’nin Adiposit Farklılaşmasındaki Rolünün İncelenmesi, GYTE Fen Bilimleri Enstitüsü, 2010.
3. Safa Aydın (Y. Lisans), Pluronik F68 Polimerinin Mezenkimal Kök Hücrelerinin Elektroporoteik Özelliklerine Etkisi. GYTE Fen Bilimleri Enstitüsü, 2011
4. Onur Z. Çaslışkaner (Y. Lisans) Endoplazmik Retikulum Stresinin SIK2 Yolağı Üzerindeki Etkisi. Fen Bilimleri Enstitüsü. GYTE, 2013.
5. Şeyma Yılmaz (Master) SIK2’nin Endoplazmik Retikulum Stresi ve 3T3-L1 Öncül Yağ Hücrelerinin Farklılaşmasına Etkisi, Fen Bilimleri Enstitüsü, 2013.
6. Meryem Topçu (Master) The Role of SIK2 in Endoplasmic Asssociate Degratdation (ERAD), Institute for Graduate Studies in Natural and Applied Sciences 2013.
7. Furkan Alkan (Master) The Effects of VEGFc and SIK2 on Polarization and Recruitment of Macrophages, Gebze Institute of Technology, Faculty of Science, 2014.
8. Tuğçe Keskin (Master) ER Stres SIK2 Etkileşiminin İnsan Yağ Hücrelerinin (Lisa2) Farklılaşmasına Etkisi, GTÜ Fen Bilimleri Enstitüsü, 2014.
9. Betsi Köse (Master) SIK2’nin ER Stresine Bağlı Muhtemel ER Yerleşik Substratlarının Araştırılması. GTÜ, Fen Bilimleri Enstitüsü, 2016.
10. İlkay G. Polat. (Master) ER stress ve SIK2’nin Karşılıklı İlişkisinin İnsan Öncül Yağ Hücresi (LiSa2) Farklılaşması Üzerine Etkisi, GTÜ, Fen Bilimleri Enstitüsü, 2017.
11. Nazlı Ertürk (Master) The Effects of SIK2 on Human Adipocyte Scretome under ER stress Conditions, Graduate School of Natural and Applied Sciences, 2017.
12. Tuncay Şeker (PhD) Proteomics Based Search for Novel SIK2 Substrates Involved in Endoplasmıc Reticulum Homeostasis Boğaziçi University, Institute for Graduate Studies in Science and Engineering, 2017.
13. M Soner Türküner (Master) Effects Of Monosodium Glutamate On 3t3-L1 Preadipocyte Differentiation,Graduate School of Natural and Applied Sciences, 2017.

  • Third Cycle (Doctoral): Moleküler Biyoloji ve Genetik, Boğaziçi Üniversitesi
  • Second Cycle (Master's): Moleküler Biyoloji, San Diego State Üniversitesi
  • First Cycle (Undergraduate): Biyoloji, Hacettepe Üniversitesi
Post Doc (2004-2006): Schlessinger Lab, Yale School of Medicine Dept. of Pharmacology, US.
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